反应详情

23 (310 mg, 0.90 mmol) was dissolved in EtOH/AcOH (4 mL/4 mL). The solution was degassed with Ar for 2 min. PtO2 (61 mg, 0.27 mmol) was added to the mixture and H2 was bubbled in for 2 min. The reaction was stirred under a H2 balloon overnight. The reaction mixture was filtered through Celite and was concentrated to yield tert-butyl 4-(2-(3-methoxy-3-oxopropyl)phenyl)piperidine-1-carboxylate. LC/MS RT (5 min method)=2.47 min. Mass observed: 248.21 (M-Boc+H).

1. customThe solution was degassed with Ar for 2 min
2. customwas bubbled in for 2 min
3. filtrationThe reaction mixture was filtered through Celite
4. concentrationwas concentrated