HuagongsheHuagongshe Chemistry Print Report · For research reference only
Tris(hydroxymethyl)aminomethane → HCID 58504863, compound
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Tris(hydroxymethyl)aminomethane | HCID 6503 | — |
| Reactant | Triethylamine | HCID 8471 | — |
| Reactant | Carbonate Ion | HCID 19660 | — |
| Reactant | 2-Chloro-6-methylbenzene-1-sulfonyl chloride | HCID 15725370 | — |
| Reactant | HCID 66997562 | HCID 66997562 | — |
| Solvent | 1,2-Dichloroethane | HCID 11 | — |
| Product | HCID 58504863 | HCID 58504863 | — |
Reaction Steps
A mixture of 20 mg (0.077 mmol) of 1-(4-methylpiperidin-1-yl)-1-oxo-4-phenylbutan-2-amine, 0.11 mmol of 2-chloro-6-methylbenzene-sulfonyl chloride, and 0.2 mmol of Et3N in 1 mL of DCE is stirred for 16 h, and 240 mg of MP-carbonate and 170 mg of PS-trisamine are added. The mixture is shaken for 2 days, filtered, and concentrated to provide Example 54.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08859814B2 |
| Source dataset | uspto-grants-2014_10 |
| ORD ID | ord-425b52e9eb3742e58906b84b5d548d32 |
| Source note | uspto-grants-2014_10 |