Tris(hydroxymethyl)aminomethane → HCID 58504863, compound

HRID 537402Notes

Reaction equation

HRID 537402 reaction equation
[CH3:1][CH:2]1[CH2:7][CH2:6][N:5]([C:8](=[O:19])[CH:9]([NH2:18])[CH2:10][CH2:11][C:12]2[CH:17]=[CH:16][CH:15]=[CH:14][CH:13]=2)[CH2:4][CH2:3]1.[Cl:20][C:21]1[CH:26]=[CH:25][CH:24]=[C:23]([CH3:27])[C:22]=1[S:28](Cl)(=[O:30])=[O:29].CCN(CC)CC.C(=O)([O-])[O-].C(O)C(N)(CO)CO>ClCCCl>[Cl:20][C:21]1[CH:26]=[CH:25][CH:24]=[C:23]([CH3:27])[C:22]=1[S:28]([NH:18][CH:9]([C:8]([N:5]1[CH2:6][CH2:7][CH:2]([CH3:1])[CH2:3][CH2:4]1)=[O:19])[CH2:10][CH2:11][C:12]1[CH:13]=[CH:14][CH:15]=[CH:16][CH:17]=1)(=[O:29])=[O:30]

Participants

7

Reactant 5

HCID 6503Tris(hydroxymethyl)aminomethaneHCID 8471TriethylamineHCID 19660Carbonate IonHCID 157253702-Chloro-6-methylbenzene-1-sulfonyl chlorideHCID 66997562HCID 66997562, compound

Product 1

HCID 58504863HCID 58504863, compound

Reagents, catalysts & solvents 1

HCID 111,2-DichloroethaneSolvent

Procedure

A mixture of 20 mg (0.077 mmol) of 1-(4-methylpiperidin-1-yl)-1-oxo-4-phenylbutan-2-amine, 0.11 mmol of 2-chloro-6-methylbenzene-sulfonyl chloride, and 0.2 mmol of Et3N in 1 mL of DCE is stirred for 16 h, and 240 mg of MP-carbonate and 170 mg of PS-trisamine are added. The mixture is shaken for 2 days, filtered, and concentrated to provide Example 54.

Workup

  1. stirringThe mixture is shaken for 2 days
  2. filtrationfiltered
  3. concentrationconcentrated
  4. customto provide Example 54

Sources & evidence

ORD record
ord-425b52e9eb3742e58906b84b5d548d32
Source dataset
uspto-grants-2014_10
Patent number
US08859814B2

Reaction notes

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