1H-indole-4-sulfonyl chloride → N-{3-(2-cyanophenyl)-1-[(4-methylpiperidin-1-yl)carbonyl]propyl}-1H-indole-4-sulfonamide

HRID 537406Notes

Reaction equation

HRID 537406 reaction equation
C(OC(=O)[NH:7][CH:8]([C:19]([N:21]1[CH2:26][CH2:25][CH:24]([CH3:27])[CH2:23][CH2:22]1)=[O:20])[CH2:9][CH2:10][C:11]1[CH:16]=[CH:15][CH:14]=[CH:13][C:12]=1[C:17]#[N:18])(C)(C)C.[NH:29]1[C:37]2[CH:36]=[CH:35][CH:34]=[C:33]([S:38](Cl)(=[O:40])=[O:39])[C:32]=2[CH:31]=[CH:30]1>>[C:17]([C:12]1[CH:13]=[CH:14][CH:15]=[CH:16][C:11]=1[CH2:10][CH2:9][CH:8]([NH:7][S:38]([C:33]1[C:32]2[CH:31]=[CH:30][NH:29][C:37]=2[CH:36]=[CH:35][CH:34]=1)(=[O:39])=[O:40])[C:19]([N:21]1[CH2:22][CH2:23][CH:24]([CH3:27])[CH2:25][CH2:26]1)=[O:20])#[N:18]

Participants

3

Reactant 2

HCID 552807991H-indole-4-sulfonyl chlorideHCID 131731952Tert-butyl{3-(2-cyanophenyl)-1-[(4-methylpiperidin-1-yl)carbonyl]propyl}carbamate

Product 1

HCID 58504908N-{3-(2-cyanophenyl)-1-[(4-methylpiperidin-1-yl)carbonyl]propyl}-1H-indole-4-sulfonamide

Procedure

Example 70 is prepared from tert-butyl{3-(2-cyanophenyl)-1-[(4-methylpiperidin-1-yl)carbonyl]propyl}carbamate and indole-4-sulfonyl chloride in the same manner that Example 5 is synthesized. ESI MS Calc. 464.2; Found: 465.2 (M+H)+.

Workup

  1. customis synthesized

Sources & evidence

ORD record
ord-8157a4ac1203406aaaf7a5e4fe2c7762
Source dataset
uspto-grants-2014_10
Patent number
US08859814B2

Reaction notes

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