Oxalyl chloride → 946488-78-4

HRID 537487Notes

Reaction equation

HRID 537487 reaction equation
[F:1][C:2]1([F:9])[CH2:5][CH:4]([C:6](O)=[O:7])[CH2:3]1.C(Cl)(=O)C([Cl:13])=O>ClCCl>[F:1][C:2]1([F:9])[CH2:5][CH:4]([C:6]([Cl:13])=[O:7])[CH2:3]1

Participants

4

Reactant 2

HCID 65578Oxalyl chlorideHCID 137777893,3-Difluorocyclobutane-1-carboxylic acid

Product 1

HCID 83855003946488-78-4Yield 50%

Reagents, catalysts & solvents 1

HCID 6344DichloromethaneSolvent

Procedure

3,3-Difluorocyclobutanecarboxylic acid (Parkway Scientific, New York, N.Y., USA) (531 mg, 3.90 mmol) was dissolved in dichloromethane (3.00 mL) and oxalyl chloride (1.02 mL, 11.7 mmol) was added. The solution was stirred at room temperature for 4 h before concentrating in vacuo to provide 3,3-difluorocyclobutanecarbonyl chloride (ca. 50% pure), which was carried on without purification.

Workup

  1. concentrationbefore concentrating in vacuo

Sources & evidence

ORD record
ord-8f0abb41d77c4158a9788c9c01380702
Source dataset
uspto-grants-2014_10
Patent number
US08859591B2

Reaction notes

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