4-Aminopyridine → HCID 58399843, compound

HRID 537659Notes

Reaction equation

HRID 537659 reaction equation
Br[C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][C:3]=1Br.[NH2:9][C:10]1[CH:15]=[CH:14][N:13]=[CH:12][CH:11]=1>>[N:13]1[CH:14]=[CH:15][C:10]([NH:9][C:3]2[C:2]([NH:9][C:10]3[CH:15]=[CH:14][N:13]=[CH:12][CH:11]=3)=[CH:7][CH:6]=[CH:5][CH:4]=2)=[CH:11][CH:12]=1

Participants

3

Reactant 2

HCID 17274-AminopyridineHCID 114141,2-Dibromobenzene

Product 1

HCID 58399843HCID 58399843, compoundYield 73.3%

Procedure

The synthesis is carried out in accordance with the general procedure of Example 2 from 56.6 g (240 mmol) of 1,2-dibromobenzene and 47.5 g (505 mmol) of 4-aminopyridine. The precipitated solid is recrystallised from toluene/acetonitrile (5:1), and the residue is washed with MeOH, giving 46.2 g (176 mmol) of a crystalline solid. The total yield is 73%.

Workup

  1. customThe precipitated solid is recrystallised from toluene/acetonitrile (5:1)
  2. washthe residue is washed with MeOH

Sources & evidence

ORD record
ord-85a6045212924c8c89f62c9013b6ba33
Source dataset
uspto-grants-2014_10
Patent number
US08865321B2

Reaction notes

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