HCID 57496383, compound → 2-Cyclohexyl-4-phenylpiperidine

HRID 537737Notes

Reaction equation

HRID 537737 reaction equation
[CH:1]1([CH:7]2[CH2:12][C:11]([C:13]3[CH:18]=[CH:17][CH:16]=[CH:15][CH:14]=3)=[CH:10][CH2:9][N:8]2C(OCC2C=CC=CC=2)=O)[CH2:6][CH2:5][CH2:4][CH2:3][CH2:2]1>CCO.[Pd]>[CH:1]1([CH:7]2[CH2:12][CH:11]([C:13]3[CH:18]=[CH:17][CH:16]=[CH:15][CH:14]=3)[CH2:10][CH2:9][NH:8]2)[CH2:2][CH2:3][CH2:4][CH2:5][CH2:6]1

Participants

4

Reactant 1

HCID 57496383HCID 57496383, compound

Product 1

HCID 574963842-Cyclohexyl-4-phenylpiperidine

Reagents, catalysts & solvents 2

HCID 23938PalladiumCatalystHCID 702EthanolSolvent

Procedure

Benzyl 2-cyclohexyl-4-phenyl-3,6-dihydropyridine-1(2H)-carboxylate (4.7 g, 12.52 mmol) in EtOH (25 ml) was added Pd/C (1.18 g, 0.554 mmol) and hydrogenated with a balloon for 10 hours. Filter through celite and concentrate. The crude piperidine was not purified. LRMS (M+H)=217.10

Workup

  1. filtrationFilter through celite
  2. concentrationconcentrate
  3. customThe crude piperidine was not purified

Sources & evidence

ORD record
ord-984b5586a16248c49f6b387ecf0a9861
Source dataset
uspto-grants-2014_10
Patent number
US08865701B2

Reaction notes

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