HCID 57496387, compound → HCID 57496388, compound

HRID 537741Notes

Reaction equation

HRID 537741 reaction equation
[F:1][C:2]1([F:30])[CH2:7][CH2:6][CH2:5][CH:4]([C@@H:8]2[CH2:13][C@H:12]([C:14]3[CH:19]=[CH:18][CH:17]=[CH:16][CH:15]=3)[CH2:11][CH2:10][N:9]2C(OCC2C=CC=CC=2)=O)[CH2:3]1>CO>[F:30][C:2]1([F:1])[CH2:7][CH2:6][CH2:5][CH:4]([C@@H:8]2[CH2:13][C@H:12]([C:14]3[CH:15]=[CH:16][CH:17]=[CH:18][CH:19]=3)[CH2:11][CH2:10][NH:9]2)[CH2:3]1

Participants

3

Reactant 1

HCID 57496387HCID 57496387, compound

Product 1

HCID 57496388HCID 57496388, compoundYield 92.4%

Reagents, catalysts & solvents 1

HCID 887MethanolSolvent

Conditions

Temperature
50 °C

Procedure

A mixture of compound 6 (130 mg, 0.31 mmol) and Pd (OH)2 (70 mg) in MeOH (20 mL) was stirred at 50° C. under H2 (50 psi) for 4 hours. The mixture was filtrated and the filtrate was concentrated to give 80 mg of (2S,4R)-2-(3,3-difluorocyclohexyl)-4-phenylpiperidine 7 in 92% yields.

Workup

  1. filtrationThe mixture was filtrated
  2. concentrationthe filtrate was concentrated

Sources & evidence

ORD record
ord-f06d1db3fd6949a0a8255159b3551e61
Source dataset
uspto-grants-2014_10
Patent number
US08865701B2

Reaction notes

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