HCID 76819802, compound → HCID 57496404, compound

HRID 537746Notes

Reaction equation

HRID 537746 reaction equation
C([N:8]1[CH2:12][CH:11]([C:13]([N:15]2[CH2:20][CH2:19][CH:18]([C:21]3[CH:26]=[CH:25][CH:24]=[CH:23][CH:22]=3)[CH2:17][CH2:16]2)=[O:14])[C:10]2([C:35]3[C:30](=[CH:31][CH:32]=[CH:33][CH:34]=3)[CH2:29][CH2:28][CH2:27]2)[CH2:9]1)C1C=CC=CC=1>CCO.[OH-].[OH-].[Pd+2]>[C:21]1([CH:18]2[CH2:17][CH2:16][N:15]([C:13]([CH:11]3[CH2:12][NH:8][CH2:9][C:10]43[C:35]3[C:30](=[CH:31][CH:32]=[CH:33][CH:34]=3)[CH2:29][CH2:28][CH2:27]4)=[O:14])[CH2:20][CH2:19]2)[CH:26]=[CH:25][CH:24]=[CH:23][CH:22]=1

Participants

4

Reactant 1

HCID 76819802HCID 76819802, compound

Product 1

HCID 57496404HCID 57496404, compound

Reagents, catalysts & solvents 2

HCID 9942167Palladium hydroxideCatalystHCID 702EthanolSolvent

Procedure

N-benzyl-4′-[(4-phenylpiperidin-1-yl)carbonyl]-3,4-dihydro-2H-spiro[naphthalene-1,3′-pyrrolidine] (0.15 g, 0.323 mmol) in EtOH (20 ml) was added Pearlman's Catalyst (0.075 g, 0.107 mmol) and hydrogenated with a balloon for 2 hours. Filtered through celite and concentrated.

Workup

  1. filtrationFiltered through celite and
  2. concentrationconcentrated

Sources & evidence

ORD record
ord-86dc768cf84c45768dee6f1355655271
Source dataset
uspto-grants-2014_10
Patent number
US08865701B2

Reaction notes

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