反应详情

温度

120 °C

N-(3-((5-(4-cyanophenyl)oxazol-2-yl)amino)phenyl)methanesulfonamide 7 (0.12 g, 0.338 mmol) was dissolved in anhydrous DMF (10 mL), Sodium azide (0.088 g, 1.35 mmol) and ammonium chloride (0.072 g, 1.35 mmol) were added to above solution. Resulting suspension was heated at 120° C. for overnight (14 hours). Reaction was cooled down and water was added. Resulting (precipitated) solid was filtered, washed with water, methanol, and water. This was further purified by dissolving into DMSO and re-precipitated with addition of water. Resulting solid was filtered, washed with water, methanol and dried under high vacuum to yield N-(3-((5-(4-(1H-tetrazol-5-yl)phenyl)oxazol-2-yl)amino)phenyl)methanesulfonamide 41 (0.12 g, 90%) as a white solid. MS (ES) m/z 398 (M+H+).

1. customResulting suspension
2. customReaction
3. temperaturewas cooled down
4. customResulting
5. custom(precipitated) solid
6. filtrationwas filtered
7. washwashed with water, methanol, and water
8. customThis was further purified
9. dissolutionby dissolving into DMSO
10. customre-precipitated with addition of water
11. customResulting solid
12. filtrationwas filtered
13. washwashed with water, methanol
14. customdried under high vacuum