反应详情

温度

88 °C

A suspension of 5,5-dimethyl-4-pyrrolidin-1-ylfuran-2(5H)-one (535 mg) in a mixture of MeOH (2 mL) and 5M HCl (8 mL) was heated at 88° C. for 2 hours. The mixture was cooled to room temp., extracted with CHCl3 (10×15 mL), combined, dried over Na2SO4, and evaporated to dryness to give 4-hydroxy-5,5-dimethyl-5H-furan-2-one as light brown solid. Yield: 359 mg, 95%.

1. temperatureThe mixture was cooled to room temp.
2. extractionextracted with CHCl3 (10×15 mL)
3. dry with materialdried over Na2SO4
4. customevaporated to dryness