反应详情

温度

0 °C

To a solution of 2-fluoro-4-methoxyacetophenone (4.45 g, 26.5 mmol) in THF (50 mL) at 0° C., a solution of 2.4 M MeMgBr (11.6 mL, 27.8 mmol) was added. The mixture was stirred at 0° C. and then room temperature for 4 h. The reaction was quenched with saturated ammonium chloride solution. The organic layer was extracted with ethyl acetate (3×50 mL). The combined ethyl acetate layers were washed with brine and dried over sodium sulfate. The title compound was obtained as an oil after flash column using EtOAc:hexane=2:8 as the elute.

1. customThe reaction was quenched with saturated ammonium chloride solution
2. extractionThe organic layer was extracted with ethyl acetate (3×50 mL)
3. washThe combined ethyl acetate layers were washed with brine
4. dry with materialdried over sodium sulfate