Potassium Carbonate → HCID 53496947, compound

Participants

Reaction Steps

1.4 141 mg (1.00 mmol) of potassium carbonate are added to a solution of 152 mg (0.40 mmol) of tert-butyl 7-(1-benzyltriazol-4-yl)pyrrolo[2,3-b]-pyrazine-5-carboxylate in 2 ml of methanol, and the mixture is stirred at room temperature for 1 hour. The reaction mixture is adsorbed onto kieselguhr and chromatographed on a silica-gel column with dichloromethane/methanol/ammonia water as eluent: 7-(1-benzyl-1H-1,2,3-triazol-4-yl)-5H-pyrrolo-[2,3-b]pyrazine (“A1”) as colourless crystals;

Provenance & Evidence