Potassium Carbonate → HCID 53496947, compound

HRID 538004Notes

Reaction equation

HRID 538004 reaction equation
C(=O)([O-])[O-].[K+].[K+].[CH2:7]([N:14]1[CH:18]=[C:17]([C:19]2[C:27]3[C:22](=[N:23][CH:24]=[CH:25][N:26]=3)[N:21](C(OC(C)(C)C)=O)[CH:20]=2)[N:16]=[N:15]1)[C:8]1[CH:13]=[CH:12][CH:11]=[CH:10][CH:9]=1>CO>[CH2:7]([N:14]1[CH:18]=[C:17]([C:19]2[C:27]3[C:22](=[N:23][CH:24]=[CH:25][N:26]=3)[NH:21][CH:20]=2)[N:16]=[N:15]1)[C:8]1[CH:13]=[CH:12][CH:11]=[CH:10][CH:9]=1

Participants

4

Reactant 2

HCID 11430Potassium CarbonateHCID 53496679HCID 53496679, compound

Product 1

HCID 53496947HCID 53496947, compound

Reagents, catalysts & solvents 1

HCID 887MethanolSolvent

Procedure

1.4 141 mg (1.00 mmol) of potassium carbonate are added to a solution of 152 mg (0.40 mmol) of tert-butyl 7-(1-benzyltriazol-4-yl)pyrrolo[2,3-b]-pyrazine-5-carboxylate in 2 ml of methanol, and the mixture is stirred at room temperature for 1 hour. The reaction mixture is adsorbed onto kieselguhr and chromatographed on a silica-gel column with dichloromethane/methanol/ammonia water as eluent: 7-(1-benzyl-1H-1,2,3-triazol-4-yl)-5H-pyrrolo-[2,3-b]pyrazine (“A1”) as colourless crystals;

Workup

  1. customchromatographed on a silica-gel column with dichloromethane/methanol/ammonia water as eluent

Sources & evidence

ORD record
ord-1550a00f05b34eb798cfae8dbd71d6e6
Source dataset
uspto-grants-2014_10
Patent number
US08865715B2

Reaction notes

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