Isatoic Anhydride → HCID 178501125, compound

Participants

Reaction Conditions

Reaction Steps

To a solution of trans-4-Aminomethyl-cyclohexanecarboxylic acid methyl ester (21.7 g, 127 mmol) in CH3CN (500 mL), K2CO3 (35 g, 254 mmol) and isatoic anhydride (20.7 g, 127 mmol) were added. The reaction was stirred at 70° C. overnight. The mixture was concentrated under reduced pressure and the residue was washed with 200 mL of H2O and the solid obtained was filtered. The titled compound (31.1 g, quantitative yield) was obtained as a white solid.

Provenance & Evidence