反应详情

温度

70 °C

To a solution of trans-4-Aminomethyl-cyclohexanecarboxylic acid methyl ester (21.7 g, 127 mmol) in CH3CN (500 mL), K2CO3 (35 g, 254 mmol) and isatoic anhydride (20.7 g, 127 mmol) were added. The reaction was stirred at 70° C. overnight. The mixture was concentrated under reduced pressure and the residue was washed with 200 mL of H2O and the solid obtained was filtered. The titled compound (31.1 g, quantitative yield) was obtained as a white solid.

1. concentrationThe mixture was concentrated under reduced pressure
2. washthe residue was washed with 200 mL of H2O
3. customthe solid obtained
4. filtrationwas filtered