関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|
| 反応物 | Acetonitrile | HCID 6342 | — |
| 反応物 | 6-methoxy-2,4-dihydro-1H-3,1-benzoxazine-2,4-dione | HCID 294479 | — |
| 反応物 | HCID 178454419 | HCID 178454419 | — |
| 生成物 | HCID 178492288 | HCID 178492288 | 70.2% |
反応手順
To a solution of 6-Methoxy-1H-benzo[d][1,3]oxazine-2,4-dione (96 mg, 0.5 mmol) in CH3CN (5 mL) K2CO3 (140 mg, 1 mmol) and 1-[trans-4-(4-Aminomethyl-cyclohexanecarbonyl)-piperazin-1-yl]-2-methyl-propan-1-one (148 mg, 0.5 mmol) were added and the reaction was heated at 50° C. for 16 h. The solvent was removed under reduced pressure, 5 mL of 0.4M Na2CO3 solution were added and the mixture was stirred for 1 h. Then 5 mL of DCM were added, the organic phase collected, dried over Na2SO4 and the solvent removed under reduced pressure. 156 mg of the titled product were obtained (yield=68%).
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|
| 特許番号 | US08865704B2 |
|---|
| 出典データセット | uspto-grants-2014_10 |
|---|
| ORD ID | ord-69e8e930a5ff432495dd142b69ae46c2 |
|---|
| 出典メモ | uspto-grants-2014_10 |
|---|
