Triethylamine → HCID 178452363, compound

Participants

Role	Name	HCID	Charge
Reactant	Triethylamine	HCID 8471	—
Reactant	tert-Butyl piperazine-1-carboxylate	HCID 143452	—
Reactant	Methanaminium, N-((dimethylamino)(3H-1,2,3-triazolo(4,5-b)pyridin-3-yloxy)methylene)-N-methyl-, hexafluorophosphate(1-) (1:1)	HCID 9886157	—
Reactant	HCID 178518591	HCID 178518591	—
Solvent	Dimethylacetamide	HCID 31374	—
Product	HCID 178452363	HCID 178452363	—

Reaction Steps

To a solution of trans-4-(2,4-Dioxo-1,4-dihydro-2H-quinazolin-3-ylmethyl)-cyclohexanecarboxylic acid (1.5 g, 4.96 mmol) in dimethylacetamide (10 mL), HATU (1.88 g, 4.96 mmol) and triethylamine (0.76 mL, 5.45 mmol) were added and the mixture left stirring at room temperature for 1 hour. Then tert-butyl-1-piperazinecarboxylate (0.92 g, 4.96 mmol) was added and the reaction left stirring for 18 h at room temperature. The solvent was removed under reduced pressure and the residue was washed with a 0.4M Na2CO3 solution. The titled compound was obtained as a white solid (2.3 g, quantitative yield).

Provenance & Evidence

DOI	10.6084/m9.figshare.5104873.v1
Patent number	US08865704B2
Source dataset	uspto-grants-2014_10
ORD ID	ord-118a809a1ee24ba19872b1380fd5a9a6
Source note	uspto-grants-2014_10