Lithium Hydroxide → HCID 178481613, compound

HRID 538057Notes

Reaction equation

HRID 538057 reaction equation
C[O:2][C:3]([C@H:5]1[CH2:10][CH2:9][C@H:8]([CH2:11][N:12]2[C:16]3[CH:17]=[C:18]([C:21]([F:24])([F:23])[F:22])[CH:19]=[CH:20][C:15]=3[N:14]([CH3:25])[C:13]2=[O:26])[CH2:7][CH2:6]1)=[O:4].[Li+].[OH-]>C1COCC1.O>[CH3:25][N:14]1[C:15]2[CH:20]=[CH:19][C:18]([C:21]([F:23])([F:22])[F:24])=[CH:17][C:16]=2[N:12]([CH2:11][C@H:8]2[CH2:9][CH2:10][C@H:5]([C:3]([OH:4])=[O:2])[CH2:6][CH2:7]2)[C:13]1=[O:26]

Participants

4

Reactant 2

HCID 3939Lithium HydroxideHCID 178501109HCID 178501109, compound

Product 1

HCID 178481613HCID 178481613, compoundYield 94.3%

Reagents, catalysts & solvents 1

HCID 21881883Oxolane--water (1/1)Solvent

Procedure

trans-4-(3-Methyl-2-oxo-6-trifluoromethyl-2,3-dihydro-benzoimidazol-1-ylmethyl)cyclohexanecarboxylic acid methyl ester (0.93 g, 2.44 mmol) were dissolved in THF/H2O (9 ml, 2/1). LiOH (129 mg, 5.4 mmol) was added and the mixture stirred at room temperature over night. The THF was evaporated with the formation of a white solid which was collected by filtration. 0.82 g (yield 94%) of the titled compound were isolated.

Workup

  1. customThe THF was evaporated with the formation of a white solid which
  2. filtrationwas collected by filtration

Sources & evidence

ORD record
ord-cb61df86c0d74cb49f82aa1ee1ae25a1
Source dataset
uspto-grants-2014_10
Patent number
US08865704B2

Reaction notes

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