反应详情

trans-4-(3-Methyl-2-oxo-6-trifluoromethyl-2,3-dihydro-benzoimidazol-1-ylmethyl)cyclohexanecarboxylic acid methyl ester (0.93 g, 2.44 mmol) were dissolved in THF/H2O (9 ml, 2/1). LiOH (129 mg, 5.4 mmol) was added and the mixture stirred at room temperature over night. The THF was evaporated with the formation of a white solid which was collected by filtration. 0.82 g (yield 94%) of the titled compound were isolated.

1. customThe THF was evaporated with the formation of a white solid which
2. filtrationwas collected by filtration