Bromomethylcyclopropane → 1-Cyclopropylmethylcytosine

HRID 538233Notes

Reaction equation

N1C=CC(N)=NC1=O.BrCC1CC1.[NH2:14][C:15]1[CH:20]=[CH:19][N:18]([CH2:21][C:22]2[CH:27]=[CH:26]C=CC=2)[C:17](=[O:28])[N:16]=1>>[NH2:14][C:15]1[CH:20]=[CH:19][N:18]([CH2:21][CH:22]2[CH2:27][CH2:26]2)[C:17](=[O:28])[N:16]=1

Participants

Reactant 3

HCID 81503Bromomethylcyclopropane

HCID 3085814-Amino-1-benzylpyrimidin-2(1H)-one

HCID 178418229Cytosine

Product 1

HCID 214443201-Cyclopropylmethylcytosine

Procedure

4-Amino-1-cyclopropylmethyl-1H-pyrimidin-2-one was prepared from cytosine and (bromomethyl)cyclopropane using the methods described above for the preparation of 4-amino-1-benzyl-1H-pyrimidin-2-one.

Sources & evidence

ORD record: ord-04e04d6499cb496d9cb2bef4d74f79e7
Source dataset: uspto-grants-2014_10
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US08865725B2

Reaction notes

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