1,3-Dichloroacetone → 6-Benzyl-2-chloromethyl-6H-imidazo[1,2-c]pyrimidin-5-one

HRID 538234Notes

Reaction equation

HRID 538234 reaction equation
[NH2:1][C:2]1[CH:7]=[CH:6][N:5]([CH2:8][C:9]2[CH:14]=[CH:13][CH:12]=[CH:11][CH:10]=2)[C:4](=[O:15])[N:3]=1.[Cl:16][CH2:17][C:18]([CH2:20]Cl)=O.ClCC1N=C2C=CN(C3C=CC(F)=CC=3)C(=O)N2C=1>>[CH2:8]([N:5]1[CH:6]=[CH:7][C:2]2=[N:1][C:18]([CH2:17][Cl:16])=[CH:20][N:3]2[C:4]1=[O:15])[C:9]1[CH:10]=[CH:11][CH:12]=[CH:13][CH:14]=1

Participants

4

Reactant 3

HCID 107931,3-DichloroacetoneHCID 3085814-Amino-1-benzylpyrimidin-2(1H)-oneHCID 682908442-chloromethyl-6-(4-fluoro-phenyl)-6H-imidazo[1,2-c]pyrimidin-5-one

Product 1

HCID 682910756-Benzyl-2-chloromethyl-6H-imidazo[1,2-c]pyrimidin-5-one

Procedure

6-Benzyl-2-chloromethyl-6H-imidazo[1,2-c]pyrimidin-5-one was prepared from 4-amino-1-benzyl-1H-pyrimidin-2-one and 1,3-dichloroacetone using the methods described above for the preparation of 2-chloromethyl-6-(4-fluoro-phenyl)-6H-imidazo[1,2-c]pyrimidin-5-one.

Sources & evidence

ORD record
ord-c438366e3dfc42969c3ac1032afeb7ab
Source dataset
uspto-grants-2014_10
Patent number
US08865725B2

Reaction notes

Loading…