1,3-Dichloroacetone → 2-Chloromethyl-6-(4-fluoro-phenyl)-8-iodo-6H-imidazo[1,2-c]pyrimidin-5-one

HRID 538238Notes

Reaction equation

HRID 538238 reaction equation
[NH2:1][C:2]1[C:7]([I:8])=[CH:6][N:5]([C:9]2[CH:14]=[CH:13][C:12]([F:15])=[CH:11][CH:10]=2)[C:4](=[O:16])[N:3]=1.[Cl:17][CH2:18][C:19]([CH2:21]Cl)=O.ClCC1N=C2C=CN(C3C=CC(F)=CC=3)C(=O)N2C=1>>[Cl:17][CH2:18][C:19]1[N:1]=[C:2]2[C:7]([I:8])=[CH:6][N:5]([C:9]3[CH:10]=[CH:11][C:12]([F:15])=[CH:13][CH:14]=3)[C:4](=[O:16])[N:3]2[CH:21]=1

Participants

4

Reactant 3

HCID 107931,3-DichloroacetoneHCID 682908442-chloromethyl-6-(4-fluoro-phenyl)-6H-imidazo[1,2-c]pyrimidin-5-oneHCID 682909404-amino-1-(4-fluoro-phenyl)-5-iodo-1H-pyrimidin-2-one

Product 1

HCID 682902672-Chloromethyl-6-(4-fluoro-phenyl)-8-iodo-6H-imidazo[1,2-c]pyrimidin-5-one

Procedure

2-Chloromethyl-6-(4-fluoro-phenyl)-8-iodo-6H-imidazo[1,2-c]pyrimidin-5-one was prepared from 4-amino-1-(4-fluoro-phenyl)-5-iodo-1H-pyrimidin-2-one and 1,3-dichloroacetone using the methods as described above for the preparation of 2-chloromethyl-6-(4-fluoro-phenyl)-6H-imidazo[1,2-c]pyrimidin-5-one.

Sources & evidence

ORD record
ord-3c601761d328480f999938dadc7a4e6a
Source dataset
uspto-grants-2014_10
Patent number
US08865725B2

Reaction notes

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