Trifluoroacetic acid → HCID 68108461, compound

HRID 538385Notes

Reaction equation

HRID 538385 reaction equation
C([O:5][C:6]([C:8]1[C:13]([NH2:14])=[CH:12][C:11]([C:15]#[N:16])=[CH:10][N:9]=1)=[O:7])(C)(C)C.COC1C=CC=C(OC)C=1.C(O)(C(F)(F)F)=O>C1(C)C=CC=CC=1>[NH2:14][C:13]1[C:8]([C:6]([OH:7])=[O:5])=[N:9][CH:10]=[C:11]([C:15]#[N:16])[CH:12]=1

Participants

5

Reactant 3

HCID 6422Trifluoroacetic acidHCID 90251,3-DimethoxybenzeneHCID 68108076HCID 68108076, compound

Product 1

HCID 68108461HCID 68108461, compound

Reagents, catalysts & solvents 1

HCID 1140TolueneSolvent

Procedure

To a mixture of 3-amino-5-cyano-pyridine-2-carboxylic acid tert-butyl ester (60 mg, 0.274 mmol) and 1,3-dimethoxybenzene (0.358 ml, 2.74 mmol) was added dropwise within 10 min TFA (0.59 ml, 7.66 mmol) and the reaction mixture was stirred for 6 h. Toluene was added and the solvents were evaporated to provide the title compound as yellow solid. The product was used for the next step without further purification.

Workup

  1. customthe solvents were evaporated

Sources & evidence

ORD record
ord-08770b3f9ef64e3385c2a393b9e16a26
Source dataset
uspto-grants-2014_10
Patent number
US08865712B2

Reaction notes

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