Hydrochloric Acid → [2,4'-Bipyridine]-3-carboxylic acid dihydrochloride

HRID 538470Notes

Reaction equation

HRID 538470 reaction equation
[N:1]1[CH:6]=[CH:5][CH:4]=[C:3]([C:7]([O:9]CC)=[O:8])[C:2]=1[C:12]1[CH:17]=[CH:16][N:15]=[CH:14][CH:13]=1.[ClH:18]>>[ClH:18].[ClH:18].[N:1]1[CH:6]=[CH:5][CH:4]=[C:3]([C:7]([OH:9])=[O:8])[C:2]=1[C:12]1[CH:17]=[CH:16][N:15]=[CH:14][CH:13]=1

Participants

3

Reactant 2

HCID 313Hydrochloric AcidHCID 46317743Ethyl [2,4'-bipyridine]-3-carboxylate

Product 1

HCID 84819756[2,4'-Bipyridine]-3-carboxylic acid dihydrochloride

Procedure

A solution of ethyl 2,4′-bipyridine-3-carboxylate (14.1 g) in 6 N hydrochloric acid (200 mL) was heated under reflux overnight. The solvent was evaporated under reduced pressure, to the obtained residue was added toluene, and the solvent was again evaporated under reduced pressure to give the title compound (16.4 g).

Workup

  1. temperatureunder reflux overnight
  2. customThe solvent was evaporated under reduced pressure, to the obtained residue
  3. additionwas added toluene
  4. customthe solvent was again evaporated under reduced pressure

Sources & evidence

ORD record
ord-0e1f949931ef4fef9d94d22b5c797141
Source dataset
uspto-grants-2014_10
Patent number
US08865717B2

Reaction notes

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