反应详情

温度

50 °C

N-[2-(3,5-di-tert-butyl-4-hydroxyphenethyl)-4,6-difluorophenyl]-N'-(1-benzyl-4-piperidyl)urea (0.50 g) was suspended in ethanol (10 ml) and heated at 50° C. to dissolve it. To the solution was added methanesulfonic acid (56 μl) and this solution was concentrated. The concentrate was dissolved with a mixed solvent of ethyl acetate (1 ml) and diisopropylether (3 ml). The solution was cooled to 0°-5° C. and allowed to stand overnight. The resultant crystals were filtered and dried to give the title compound (0.51 g, 87%).

1. dissolutionto dissolve it
2. concentrationthis solution was concentrated
3. dissolutionThe concentrate was dissolved with a mixed solvent of ethyl acetate (1 ml) and diisopropylether (3 ml)
4. temperatureThe solution was cooled to 0°-5° C.
5. filtrationThe resultant crystals were filtered
6. customdried