2,6-Difluoro-3-hydroxybenzamide → HCID 46237271, compound

HRID 538542Notes

Reaction equation

HRID 538542 reaction equation
[F:1][C:2]1[C:7]([OH:8])=[CH:6][CH:5]=[C:4]([F:9])[C:3]=1[C:10]([NH2:12])=[O:11].Cl[CH2:14][C:15]1[S:16][C:17]2[CH:23]=[C:22]([O:24][CH3:25])[CH:21]=[CH:20][C:18]=2[N:19]=1>>[F:1][C:2]1[C:7]([O:8][CH2:14][C:15]2[S:16][C:17]3[CH:23]=[C:22]([O:24][CH3:25])[CH:21]=[CH:20][C:18]=3[N:19]=2)=[CH:6][CH:5]=[C:4]([F:9])[C:3]=1[C:10]([NH2:12])=[O:11]

Participants

3

Reactant 2

HCID 451201362,6-Difluoro-3-hydroxybenzamideHCID 594027092-Chloromethyl-6-methoxybenzothiazole

Product 1

HCID 46237271HCID 46237271, compoundYield 19%

Procedure

Synthesised from 2,6-difluoro-3-hydroxybenzenecarboxamide and 2-(chloromethyl)-6-methoxy-1,3-benzothiazole according to Method B, scheme 2. Yield 19%, mp 190-192° C., HPLC-MS (method 1): m/z 351 [M+H]+, Rt=3.50 min.

Sources & evidence

ORD record
ord-101c757e9bbe49e5a2a610ea02fcc589
Source dataset
uspto-grants-2014_10
Patent number
US08865736B2

Reaction notes

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