2-Methyl-2-(tetrahydro-pyran-4-ylmethanesulfonyl)-propionic acid → HCID 86297382, compound

HRID 538645Notes

Reaction equation

HRID 538645 reaction equation
[CH3:1][C:2]([S:7]([CH2:10][CH:11]1[CH2:16][CH2:15][O:14][CH2:13][CH2:12]1)(=[O:9])=[O:8])([CH3:6])[C:3]([OH:5])=O.[NH2:17][C:18]1[O:22][N:21]=[C:20]([C:23]([CH3:27])([CH3:26])[C:24]#[N:25])[CH:19]=1>>[C:24]([C:23]([CH3:27])([CH3:26])[C:20]1[CH:19]=[C:18]([NH:17][C:3](=[O:5])[C:2]([CH3:1])([S:7]([CH2:10][CH:11]2[CH2:16][CH2:15][O:14][CH2:13][CH2:12]2)(=[O:9])=[O:8])[CH3:6])[O:22][N:21]=1)#[N:25]

Participants

3

Reactant 2

HCID 597039922-Methyl-2-(tetrahydro-pyran-4-ylmethanesulfonyl)-propionic acid2×HCID 668766082-(5-Aminoisoxazol-3-yl)-2-methylpropanenitrile2×

Product 1

HCID 86297382HCID 86297382, compound

Procedure

Prepared according to procedure of example 1 starting from 100 mg (0.40 mmol) of 2-methyl-2-(tetrahydro-pyran-4-ylmethanesulfonyl)-propionic acid (intermediate 2) and 66.4 mg (0.44 mmol) 2-(5-amino-isoxazol-3-yl)-2-methyl-propionitrile (intermediate 7).

Workup

  1. customPrepared

Sources & evidence

ORD record
ord-902ee0444bcd41d1a52d9a1fd9896e58
Source dataset
uspto-grants-2014_10
Patent number
US08865744B1

Reaction notes

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