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HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 538645Generated: October 30, 2026

2-Methyl-2-(tetrahydro-pyran-4-ylmethanesulfonyl)-propionic acid → US10112934, Example 2

https://huagongshe.com/reaction/538645

Reaction equation

Participants

RoleNameHCIDCharge
Reactant2-Methyl-2-(tetrahydro-pyran-4-ylmethanesulfonyl)-propionic acidHCID 59703992—
Reactant2-(5-Aminoisoxazol-3-yl)-2-methylpropanenitrileHCID 66876608—
ProductUS10112934, Example 2HCID 86297382—

Reaction Steps

Prepared according to procedure of example 1 starting from 100 mg (0.40 mmol) of 2-methyl-2-(tetrahydro-pyran-4-ylmethanesulfonyl)-propionic acid (intermediate 2) and 66.4 mg (0.44 mmol) 2-(5-amino-isoxazol-3-yl)-2-methyl-propionitrile (intermediate 7).

Provenance & Evidence

DOI10.6084/m9.figshare.5104873.v1
Patent numberUS08865744B1
Source datasetuspto-grants-2014_10
ORD IDord-902ee0444bcd41d1a52d9a1fd9896e58
Source noteuspto-grants-2014_10