Methyl iodide → HCID 60164183, compound

HRID 538665Notes

Reaction equation

HRID 538665 reaction equation
[CH3:1][N:2]1[CH2:7][CH2:6][CH2:5][CH2:4][CH:3]1[CH2:8][N:9]([CH:16]1[CH2:24][C:23]2[C:18](=[CH:19][CH:20]=[CH:21][CH:22]=2)[CH2:17]1)[C:10]1[CH:15]=[CH:14][CH:13]=[CH:12][CH:11]=1.[CH3:25][I:26]>ClCCCl>[I-:26].[CH3:1][N+:2]1([CH3:25])[CH2:7][CH2:6][CH2:5][CH2:4][CH:3]1[CH2:8][N:9]([CH:16]1[CH2:24][C:23]2[C:18](=[CH:19][CH:20]=[CH:21][CH:22]=2)[CH2:17]1)[C:10]1[CH:15]=[CH:14][CH:13]=[CH:12][CH:11]=1

Participants

4

Reactant 2

HCID 6328Methyl iodideHCID 9798809HCID 9798809, compound

Product 1

HCID 60164183HCID 60164183, compound

Reagents, catalysts & solvents 1

HCID 111,2-DichloroethaneSolvent

Procedure

To a stirred solution of compound 17 (0.1 g, 0.31 mmol) in DCE (5 mL) was added methyl iodide (0.058 mL, 0.94 mmol) and the resulting mixture was stirred at rt for 16 hours. The reaction mixture was concentrated under reduced pressure and the crude material was purified by crystallization from methanol-ether to provide 1,1-dimethyl-2-[((indan-2-yl)(phenyl)amino)methyl]piperidinium iodide.

Workup

  1. concentrationThe reaction mixture was concentrated under reduced pressure
  2. customthe crude material was purified by crystallization from methanol-ether

Sources & evidence

ORD record
ord-44ccde7ef5dc48a4b95d0f3a690a8990
Source dataset
uspto-grants-2014_10
Patent number
US08865741B2

Reaction notes

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