反应详情

To a stirred suspension of morphine (4 g, 14 mmol) in 10% aqueous sodium bicarbonate (377 ml) was added acetic anhydride (19 ml) over 8.5 minutes. 15 minutes after the addition, ice cold water (300 ml) was added and the solution was extracted with dichloromethane (200 ml). The organic extract was washed with brine, dried over Na2SO4, and the solvent removed in vacuo to leave a sticky white residue. Trituration with ether gave 3-acetylmorphine (3.68 g, 80%). The corresponding 3-pivalyl, 3-isobutyryl, 3-propionyl and other 3-acyl derivatives of morphine were also prepared.

1. additionwas added
2. extractionthe solution was extracted with dichloromethane (200 ml)
3. extractionThe organic extract
4. washwas washed with brine
5. dry with materialdried over Na2SO4
6. customthe solvent removed in vacuo
7. customto leave a sticky white residue