反应详情

To a stirred solution of LAH (0.94 g, 24.69 mmol) in dry THF (100 mL) was added solution of compound 36 (3.0 g 12.34 mmol) in THF (40 mL) at 0° C. and stirred at rt for 16 hours. The reaction mixture was quenched with brine solution and filtered through a Celite® bed. The organic layer was dried over anhydrous Na2SO4 and evaporated. The crude was purified by Combiflash® chromatography eluting with 2-3% of methanol-DCM to provide liquid compound 37.

1. customThe reaction mixture was quenched with brine solution
2. filtrationfiltered through a Celite® bed
3. dry with materialThe organic layer was dried over anhydrous Na2SO4
4. customevaporated
5. customThe crude was purified by Combiflash® chromatography
6. washeluting with 2-3% of methanol-DCM