Succinimide → 1-(2-{4-[3-(3,4-dimethoxyphenyl)-4-methyl-5-oxo-4-propyl-4,5-dihydro-1H-pyrazol-1-yl]piperidin-1-yl}-2-oxoethyl)pyrrolidine-2,5-dione

HRID 538703Notes

Reaction equation

HRID 538703 reaction equation
Cl[CH2:2][C:3]([N:5]1[CH2:10][CH2:9][CH:8]([N:11]2[C:15](=[O:16])[C:14]([CH3:20])([CH2:17][CH2:18][CH3:19])[C:13]([C:21]3[CH:26]=[CH:25][C:24]([O:27][CH3:28])=[C:23]([O:29][CH3:30])[CH:22]=3)=[N:12]2)[CH2:7][CH2:6]1)=[O:4].[C:31]1(=[O:37])[NH:35][C:34](=[O:36])[CH2:33][CH2:32]1>>[CH3:30][O:29][C:23]1[CH:22]=[C:21]([C:13]2[C:14]([CH3:20])([CH2:17][CH2:18][CH3:19])[C:15](=[O:16])[N:11]([CH:8]3[CH2:9][CH2:10][N:5]([C:3](=[O:4])[CH2:2][N:35]4[C:31](=[O:37])[CH2:32][CH2:33][C:34]4=[O:36])[CH2:6][CH2:7]3)[N:12]=2)[CH:26]=[CH:25][C:24]=1[O:27][CH3:28]

Participants

3

Reactant 2

HCID 11439SuccinimideHCID 666167362-[1-(chloroacetyl)piperidin-4-yl]-5-(3,4-dimethoxyphenyl)-4-methyl-4-propyl-2,4-dihydro-3H-pyrazol-3-one2×

Product 1

HCID 251165421-(2-{4-[3-(3,4-dimethoxyphenyl)-4-methyl-5-oxo-4-propyl-4,5-dihydro-1H-pyrazol-1-yl]piperidin-1-yl}-2-oxoethyl)pyrrolidine-2,5-dione

Procedure

Prepared analogously as described for example 1 using 2-[1-(chloroacetyl)piperidin-4-yl]-5-(3,4-dimethoxyphenyl)-4-methyl-4-propyl-2,4-dihydro-3H-pyrazol-3-one (compound A8) and succinimide as starting compounds.

Workup

  1. customPrepared analogously

Sources & evidence

ORD record
ord-9cec7d032a78485c82cbe3bb62440217
Source dataset
uspto-grants-2014_10
Patent number
US08865745B2

Reaction notes

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