反应详情

10.2 g (40 mmol, 90% pure) of 7-benzyl-1-cyano-2-oxa-7-aza-bicyclo[3.3.0]octane are added dropwise to 2 g of lithium aluminium hydride in 100 ml of absolute tetrahydrofuran and the mixture is subsequently stirred under reflux for 15 hours. 2 ml each of water, 15% strength potassium hydroxide solution, and again water, are added dropwise, the inorganic salts are filtered off with suction, and the filtrate is concentrated and distilled. Yield: 7.7 g (83% of theory).

1. temperatureunder reflux for 15 hours
2. filtrationthe inorganic salts are filtered off with suction
3. concentrationthe filtrate is concentrated
4. distillationdistilled