反应详情

12.2 g (34.5 mmol) of 7-benzyl-1-tert-butoxycarbonylaminomethyl-2-oxa-7-aza-bicyclo[3.3.0]octane are hydrogenated in 200 ml of ethanol on 7 g of palladium-active charcoal (10% Pd) at 100° C. and 100 bar. The catalyst is filtered off with suction and the filtrate is concentrated and distilled. Yield: 5.7 g (68% of theory) Boiling point: 120°-130° C./0.01 mbar.

1. filtrationThe catalyst is filtered off with suction
2. concentrationthe filtrate is concentrated
3. distillationdistilled