HuagongsheHuagongshe Chemistry Print Report · For research reference only
7-Benzyl-1-tert-butoxycarbonylaminomethyl-2-oxa-7-azabicyclo[3.3.0]octane → 1-Tert-butoxycarbonylaminomethyl-2-oxa-7-aza-bicyclo[3.3.0]octane
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 7-Benzyl-1-tert-butoxycarbonylaminomethyl-2-oxa-7-azabicyclo[3.3.0]octane | HCID 21704751 | — |
| Catalyst | Palladium | HCID 23938 | — |
| Solvent | Ethanol | HCID 702 | — |
| Product | 1-Tert-butoxycarbonylaminomethyl-2-oxa-7-aza-bicyclo[3.3.0]octane | HCID 21704749 | — |
Reaction Steps
12.2 g (34.5 mmol) of 7-benzyl-1-tert-butoxycarbonylaminomethyl-2-oxa-7-aza-bicyclo[3.3.0]octane are hydrogenated in 200 ml of ethanol on 7 g of palladium-active charcoal (10% Pd) at 100° C. and 100 bar. The catalyst is filtered off with suction and the filtrate is concentrated and distilled. Yield: 5.7 g (68% of theory) Boiling point: 120°-130° C./0.01 mbar.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US05621105 |
| Source dataset | uspto-grants-1997_04 |
| ORD ID | ord-c143780869ab4d41ab651f0a337b60ed |
| Source note | uspto-grants-1997_04 |