HuagongsheHuagongshe Chemistry Print Report · For research reference only
Hydrochloric Acid → 4-Methyl-2-methylene valeric acid
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Hydrochloric Acid | HCID 313 | — |
| Reactant | Ethyl 4-methyl-2-methylenepentanoate | HCID 10909818 | — |
| Solvent | Potassium Hydroxide | HCID 14797 | — |
| Product | 4-Methyl-2-methylene valeric acid | HCID 168659 | 99.1% |
Reaction Steps
Saponification of 6.32 g (40.4 mmol) ethyl 2-isobutylacrylate was carried out 50 ml of 20% aqueous KOH at reflux. The obtained mixture was acidified by aqueous HCl to pH=5-6, and the product was extracted by 2×100 ml of dichloromethane. The organic extract was evaporated to dryness to give 5.13 g (99%) 2-isobutylacrylic acid which was further used without an additional purification.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08865848B2 |
| Source dataset | uspto-grants-2014_10 |
| ORD ID | ord-61225128229a48d3a3819e2eb4be8673 |
| Source note | uspto-grants-2014_10 |