Hydrochloric Acid → 1-(2-chlorobenzo[d]thiazol-6-yl)-N-ethyl-1-(1H-imidazol-1-yl)-N-methylbutan-2-amine

HRID 538871Notes

Reaction equation

HRID 538871 reaction equation
Br[C:2]1[S:3][C:4]2[CH:10]=[C:9]([CH:11]([N:19]3[CH:23]=[CH:22][N:21]=[CH:20]3)[CH:12]([N:15]([CH2:17][CH3:18])[CH3:16])[CH2:13][CH3:14])[CH:8]=[CH:7][C:5]=2[N:6]=1.[ClH:24]>>[Cl:24][C:2]1[S:3][C:4]2[CH:10]=[C:9]([CH:11]([N:19]3[CH:23]=[CH:22][N:21]=[CH:20]3)[CH:12]([N:15]([CH2:17][CH3:18])[CH3:16])[CH2:13][CH3:14])[CH:8]=[CH:7][C:5]=2[N:6]=1

Participants

3

Reactant 2

HCID 313Hydrochloric AcidHCID 547620861-(2-bromobenzo[d]thiazol-6-yl)-N-ethyl-1-(1H-imidazol-1-yl)-N-methylbutan-2-amine

Product 1

HCID 547620881-(2-chlorobenzo[d]thiazol-6-yl)-N-ethyl-1-(1H-imidazol-1-yl)-N-methylbutan-2-amine

Procedure

A mixture of 1-(2-bromobenzo[d]thiazol-6-yl)-N-ethyl-1-(1H-imidazol-1-yl)-N-methylbutan-2-amine (5 mg, 0.1 mmol) and 2N HCl (5 in L) was stirred at Rt for 1 h. The mixture was filtered and evaporated to afford 1-(2-chlorobenzo[d]thiazol-6-yl)-N-ethyl-1-(1H-imidazol-1-yl)-N-methylbutan-2-amine. MS ESI: m/z 349.2 [M+H+].

Workup

  1. filtrationThe mixture was filtered
  2. customevaporated

Sources & evidence

ORD record
ord-10e7ab63d63448489b852cd00ac6ef72
Source dataset
uspto-grants-2014_10
Patent number
US08865752B2

Reaction notes

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