反应详情

温度

0 °C

To a solution of benzyl [3-(formylamino)propyl]-carbamate (15.8 g, 67.0 mmol) in 300 mL of dry CH2Cl2 was added diisopropylamine (29.6 mL, 211 mmol). The solution was cooled down to 0° C. using an ice bath. Then, POCl3 (7.36 mL, 80.0 mmol) was slowly added dropwise. After warming to room temperature, the solution was stirred for a further 3 h. Addition of 20 g of Na2CO3, dissolved in 100 mL of distilled H2O, was followed by further stirring at RT for 30 min. The reaction mixture was subsequently diluted with 100 mL of CH2Cl2 and also 100 mL of distilled H2O and the aqueous phase was extracted 3× with 150 mL of CH2Cl2 each time. The combined organic phases were dried over Na2SO4 and concentrated in a rotary evaporator. Purification by column chromatography (MeOH/CH2Cl2, 1/9, v/v) gave a dark brown liquid (13.0 g, 89%).

1. temperatureAfter warming to room temperature
2. stirringby further stirring at RT for 30 min
3. extractionthe aqueous phase was extracted 3× with 150 mL of CH2Cl2 each time
4. dry with materialThe combined organic phases were dried over Na2SO4
5. concentrationconcentrated in a rotary evaporator
6. customPurification by column chromatography (MeOH/CH2Cl2, 1/9, v/v)