2-Amino-2-(2-bromophenyl)acetic acid → HCID 14853184, compound

To a stirred solution of 2-amino-2-(2-bromophenyl)acetic acid (4.89 g, 21.3 mmol) in THF (50 mL) was added dropwise a solution of LiAlH4 in THF (1.0 M, 42.5 mL, 42.5 mmol) at 0° C. under N2. The reaction was allowed to warm to ambient temperature and stirred for 4 hours. The reaction mixture was cooled to 0° C. and carefully quenched by dropwise addition of water (1.7 mL) followed by 15% NaOH solution (1.7 mL) and water (5.1 mL). The mixture was stirred at ambient temperature for 15 minutes and filtered through Celite. The filtrate was concentrated to give crude 2-amino-2-(2-bromophenyl)ethanol, which was used in the next step without further purification.

1. temperatureThe reaction mixture was cooled to 0° C.
2. customcarefully quenched by dropwise addition of water (1.7 mL)
3. stirringThe mixture was stirred at ambient temperature for 15 minutes
4. filtrationfiltered through Celite
5. concentrationThe filtrate was concentrated

ORD record

ord-8afb829c4c7343829573f8da7c8b5c4b

Source dataset

uspto-grants-2014_10

DOI

10.6084/m9.figshare.5104873.v1

Patent number

US08865726B2