HRID539310

反应详情

EQUATION

反应方程式

REACTANTS

反应物

HCID7294

Methyl acrylate

C4H6O2

HCID67979342

未命名化合物

2 次

HCID67979557

5′-(3-Fluoropropoxy)spiro[cyclohexane-1,2′-[2H]indene]-3′,4(1′H)-dione

C17H19FO3

PRODUCTS

生成物

结构：O=C1CCC2(CC1)Cc1ccc(OCCC(F)(F)F)cc1C2=O

HCID67979397

5′-(3,3,3-Trifluoropropoxy)spiro[cyclohexane-1,2′-[2H]indene]-3′,4(1′H)-dione

C17H17F3O3

收率 58%

PROCEDURE

实验过程

The title compound (854 mg, 58% yield) was prepared using the method described for Intermediate 63 starting from 6-(3,3,3-trifluoropropoxy)-2,3-dihydro-1H-inden-1-one (Intermediate 47, 1.08 g, 4.42 mmol) and methyl acrylate (878 μL, 9.73 mmol): 1H NMR (500 MHz, CDCl3) δ ppm 1.82-1.92 (m, 2 H), 2.17-2.27 (m, 2 H), 2.42-2.53 (m, 2 H), 2.60-2.75 (m, 4 H), 3.14-3.20 (m, 2 H), 4.22-4.27 (m, 2 H), 7.19-7.22 (m, 1 H), 7.25 (dd, 1 H), 7.41 (d, 1 H): MS (ES+) m/z 327 [M+H]+.