反应详情

13.31 g of 2-acetyl-4-bromophenol, 11.0 g of ethyl bromoacetate and 9.7 g of anhydrous potassium carbonate were refluxed under heating in 70 ml of acetone for 2 hours. Insoluble materials were removed by filtration, and the resulting filtrate was concentrated and dried. The residue thus obtained was dissolved in chloroform, washed with water, and then dried to remove the solvent. The thus treated residue was washed with a mixed solvent system of ethanol and n-hexane to isolate insoluble crystals by filtration. In this way, 16.82 g of ethyl (2-acetyl-4-bromophenyl)oxyacetate was obtained in the form of colorless plate crystals.

1. customInsoluble materials were removed by filtration
2. concentrationthe resulting filtrate was concentrated
3. customdried
4. customThe residue thus obtained
5. washwashed with water
6. customdried
7. customto remove the solvent
8. washThe thus treated residue was washed with a mixed solvent system of ethanol and n-hexane
9. customto isolate insoluble crystals
10. filtrationby filtration