反应详情

Reaction of 158c (0.25 g, 0.62 mmol) in anhydrous THF as described for synthesis of 159b gave 159c (0.12 g, 63%) of pure product. 1H NMR (400 MHz, CDCl3) δ 7.79 (m, 3H), 7.41 (t, J=7.6 Hz, 2H), 7.32 (t, J=7.4 Hz, 1H), 6.76 (m, 3H), 6.13 (t, J=7.2 Hz, 1H), 4.45 (t, J=6.8 Hz, 2H), 4.02 (t, J=7.1 Hz, 2H), 1.99 (m, 2H), 1.82 (m, 2H). 13C NMR (100 MHz, CDCl3) δ 158.47, 147.63, 146.62, 130.41, 128.69, 127.99, 126.60, 125.53, 119.80, 114.15, 107.10, 49.38, 48.57, 27.02, 26.01. HRMS (EI) calcd for C17H18N4O2 [M]+ 310.1430. found 310.1425.