反应详情

Reaction of 158d (0.085 g, 0.20 mmol) in anhydrous THF as described for synthesis of 159b gave 159d (0.045 g, 68%) of pure product. 1H NMR (400 MHz, DMSO) δ 8.56 (s, 1H), 7.82 (d, J=8.1 Hz, 2H), 7.43 (t, J=7.7 Hz, 2H), 7.32 (t, J=7.4 Hz, 1H), 7.10 (dd, J=6.8, 1.6 Hz, 1H), 6.65 (dd, J=7.2, 1.5 Hz, 1H), 6.05 (1, J=7.0 Hz, 1H), 4.38 (t, J=7.0 Hz, 2H), 3.89 (t, J=7.2 Hz, 2H), 1.89 (m, 2H), 1.67 (m, 2H), 1.25 (m, 2H). 13C NMR (100 MHz, CDCl3) δ 158.44, 147.67, 146.61, 130.51, 128.72, 128.01, 126.71, 125.57, 119.54, 113.81, 106.86, 49.86, 49.38, 29.58, 28.31, 23.19. HRMS (FAB) calcd for C18H21N4O2 [M+H]+ 325.1664. found 325.1683.