反应详情

Reaction of 158e (0.15 g, 0.35 mmol) in anhydrous THF as described for synthesis of 159b gave 159e (0.081 g, 69%) of pure product. 1H NMR (400 MHz, CDCl3) δ 7.81 (m, 3H), 7.42 (m, 2H), 7.32 (m, 1H), 6.77 (m, 2H), 6.12 (t, J=7.1 Hz, 1H), 4.38 (t, J=7.1 Hz, 2H), 3.95 (m, 2H), 1.95 (m, 2H), 1.76 (d, J=7.0 Hz, 2H), 1.39 (m, 4H). 13C NMR (100 MHz, CDCl3) δ 158.20, 147.25, 146.40, 130.30, 128.60, 127.85, 126.65, 125.40, 119.65, 113.90, 106.80, 50.20, 49.60, 30.05, 28.95, 26.00, 25.90. HRMS (FAB) calcd for C19H23N4O2 [M+H]+ 339.1821. found 339.1814.