Hydrochloric Acid → HCID 66906141, compound

HRID 539562Notes

Reaction equation

HRID 539562 reaction equation
C(OC(=O)[NH:7][C@H:8]([C:22]1[CH:27]=[CH:26][CH:25]=[CH:24][CH:23]=1)[C:9]([NH:11][C:12]1[CH:13]=[C:14]2[C:19](=[CH:20][CH:21]=1)[CH:18]=[N:17][CH:16]=[CH:15]2)=[O:10])(C)(C)C.[ClH:29]>C(Cl)Cl>[ClH:29].[ClH:29].[NH2:7][C@H:8]([C:22]1[CH:27]=[CH:26][CH:25]=[CH:24][CH:23]=1)[C:9]([NH:11][C:12]1[CH:13]=[C:14]2[C:19](=[CH:20][CH:21]=1)[CH:18]=[N:17][CH:16]=[CH:15]2)=[O:10]

Participants

4

Reactant 2

HCID 313Hydrochloric AcidHCID 57788120HCID 57788120, compound

Product 1

HCID 66906141HCID 66906141, compound

Reagents, catalysts & solvents 1

HCID 6344DichloromethaneSolvent

Procedure

To (R)-tert-butyl-2-(isoquinolin-6-ylamino)-2-oxo-1 phenyl-ethylcarbamate (E1) in CH2Cl2 was added HCl (4M in dioxane) and the solution was stirred overnight at room temperature. The reaction was concentrated to give (R)-2-amino-N-(isoquinolin-6-yl)-2-phenylacetamide dihydrochloride (E2).

Workup

  1. concentrationThe reaction was concentrated

Sources & evidence

ORD record
ord-550087e091dc469f839a25bfc43ee631
Source dataset
uspto-grants-2014_10
Patent number
US08871757B2

Reaction notes

Loading…