反应详情

A mixture of methyl 2-bromo-5-methylbenzoate (5.2 g), pyridine-4-boronic acid (4.2 g), sodium carbonate (4.8 g), tetrakis(triphenylphosphine)palladium(0) (1.3 g), water (10 mL) and DME (50 mL) was heated under reflux overnight under a nitrogen atmosphere. The reaction mixture was diluted with ethyl acetate, and filtered through silica gel. The filtrate was concentrated under reduced pressure, and the residue was purified by silica gel column chromatography (ethyl acetate/hexane) to give the title compound (2.5 g).

1. temperaturewas heated
2. temperatureunder reflux overnight under a nitrogen atmosphere
3. filtrationfiltered through silica gel
4. concentrationThe filtrate was concentrated under reduced pressure
5. customthe residue was purified by silica gel column chromatography (ethyl acetate/hexane)