Hydrochloric Acid → 5-Methyl-2-(pyridin-4-yl)benzoic acid hydrochloride

HRID 539658Notes

Reaction equation

HRID 539658 reaction equation
[CH3:1][C:2]1[CH:3]=[CH:4][C:5]([C:12]2[CH:17]=[CH:16][N:15]=[CH:14][CH:13]=2)=[C:6]([CH:11]=1)[C:7]([O:9]C)=[O:8].[ClH:18]>C(O)(=O)C>[ClH:18].[CH3:1][C:2]1[CH:3]=[CH:4][C:5]([C:12]2[CH:17]=[CH:16][N:15]=[CH:14][CH:13]=2)=[C:6]([CH:11]=1)[C:7]([OH:9])=[O:8]

Participants

4

Reactant 2

HCID 313Hydrochloric AcidHCID 86680841Methyl 5-methyl-2-(pyridin-4-yl)benzoate

Product 1

HCID 866808425-Methyl-2-(pyridin-4-yl)benzoic acid hydrochloride

Reagents, catalysts & solvents 1

HCID 176Acetic AcidSolvent

Procedure

A mixture of methyl 5-methyl-2-(pyridin-4-yl)benzoate (8.8 g), 6 N hydrochloric acid (65 mL) and acetic acid (100 mL) was heated under reflux overnight. The solvent was evaporated under reduced pressure, and the obtained solid was washed with ethyl acetate to give the title compound (6.6 g).

Workup

  1. temperaturewas heated
  2. temperatureunder reflux overnight
  3. customThe solvent was evaporated under reduced pressure
  4. washthe obtained solid was washed with ethyl acetate

Sources & evidence

ORD record
ord-ffbc898231864c06baaeefc6a8ca7f6a
Source dataset
uspto-grants-2014_10
Patent number
US08871766B2

Reaction notes

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