反应详情

温度

80 °C

Iron (0.140 g) is added to a mixture of 6-chloro-2-[3-nitro-4-(trifluoromethyl)phenyl]imidazo[1,2-a]pyridine (0.171 g), HOAc (0.230 mL) and EtOH—H2O (2 mL, 4:1). The mixture is stirred at 80° C. for 2 hours, then cooled, concentrated, taken into sat. NaHCO3 aqueous solution, extracted with EtOAc and CH2Cl2. Organics are dried and concentrated to give the title compound (150 mg, 96% yield), which is used without further purification. LCMS m/z=312.4 [M+H]+, tR=1.96 min.

1. temperaturecooled
2. concentrationconcentrated
3. extractionextracted with EtOAc and CH2Cl2
4. customOrganics are dried
5. concentrationconcentrated