反应详情

温度

220 °C

A mixture of 2-[3-bromo-4-(trifluoromethyl)phenyl]-6-ethoxy-imidazo[2,1-f]pyridazine (0.050 g, 0.129 mmol) and CuCN (0.058 g) in 4-methylmorpholine (2.0 mL) is heated in the microwave at 220° C. for 10 min. The mixture is diluted with MeOH (10 mL) and the solids are removed by filtration. The crude solution is concentrated to remove the MeOH. Water (50 mL) is added and the solid precipitate is collected. The crude product is purified by silica gel chromatography (0-100% EtOAc in Hexanes) to give the title compound (0.03 g, 71% yield). LCMS m/z=333.3 [M+H]+.

1. customthe solids are removed by filtration
2. concentrationThe crude solution is concentrated
3. customto remove the MeOH
4. additionWater (50 mL) is added
5. customthe solid precipitate is collected
6. customThe crude product is purified by silica gel chromatography (0-100% EtOAc in Hexanes)