Methyl bromoacetate → HCID 68089040, compound

HRID 539782Notes

Reaction equation

HRID 539782 reaction equation
[F:1][C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][C:3]=1[C:8]1[N:13]=[N:12][C:11]([NH2:14])=[CH:10][CH:9]=1.[Br:15][CH2:16][C:17]([O:19][CH3:20])=[O:18]>C(#N)C>[BrH:15].[F:1][C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][C:3]=1[C:8]1[CH:9]=[CH:10][C:11](=[NH:14])[N:12]([CH2:16][C:17]([O:19][CH3:20])=[O:18])[N:13]=1

Participants

4

Reactant 2

HCID 60984Methyl bromoacetateHCID 457878336-(2-fluorophenyl)pyridazin-3-amine

Product 1

HCID 68089040HCID 68089040, compoundYield 76.7%

Reagents, catalysts & solvents 1

HCID 6342AcetonitrileSolvent

Conditions

Temperature
0 °C

Procedure

A stirred solution of 6-(2-fluorophenyl)pyridazin-3-amine (0.500 g, 2.64 mmol) and methyl 2-bromoacetate (2.90 mmol) in acetonitrile (15 mL) is heated at 80° C. for 4 hours. The mixture is cooled to 0° C. and precipitate collected by filtration, washed with cold acetonitrile (2×10 mL) to afford the title compound (0.693 g, 76%) as a white solid: LCMS (m/z)=262.3 [M+H]+, tR=0.47 min.

Workup

  1. filtrationprecipitate collected by filtration
  2. washwashed with cold acetonitrile (2×10 mL)

Sources & evidence

ORD record
ord-ab5d4003f3224d8da94bcd9fa362c07a
Source dataset
uspto-grants-2014_10
Patent number
US08871767B2

Reaction notes

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